Drug interactions
Asenapine + Avanafil
Severity: Moderate
Asenapine and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, asenapine through alpha-adrenergic blockade and avanafil through vasodilation. Used together they may cause additive hypotension, dizziness or syncope, particularly after the first doses or a dose increase.
What this interaction means in plain words
Asenapine and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Avanafil belongs to Genitourinary.
Why it happens
Additive vasodilatory and alpha-blocking pharmacodynamic effects on blood pressure.
What to do
Start avanafil at the lowest dose and counsel the patient about orthostatic symptoms. Monitor blood pressure after initiation or dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Avanafil?
MediHelp rates the interaction as moderate. Asenapine and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure, asenapine through alpha-adrenergic blockade and avanafil through vasodilation. Used together they may cause additive hypotension, dizziness or syncope, particularly after the first doses or a dose increase.
How serious is the interaction between Asenapine and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at the lowest dose and counsel the patient about orthostatic symptoms. Monitor blood pressure after initiation or dose changes.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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