Drug interactions
Asenapine + Disopyramide
Severity: Major
Asenapine and Disopyramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is a class Ia antiarrhythmic with a well-known risk of QT prolongation and torsades de pointes. Adding asenapine, which also lengthens the QTc, increases the chance of a serious ventricular arrhythmia.
What this interaction means in plain words
Asenapine and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Disopyramide belongs to Cardiovascular.
Why it happens
Additive blockade of cardiac potassium channels leading to QT prolongation.
What to do
Avoid concurrent use and select an alternative antipsychotic or antiarrhythmic. If it cannot be avoided, monitor ECG closely and maintain normal potassium and magnesium levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Asenapine with Disopyramide?
MediHelp rates the interaction as major. Asenapine and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide is a class Ia antiarrhythmic with a well-known risk of QT prolongation and torsades de pointes. Adding asenapine, which also lengthens the QTc, increases the chance of a serious ventricular arrhythmia.
How serious is the interaction between Asenapine and Disopyramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select an alternative antipsychotic or antiarrhythmic. If it cannot be avoided, monitor ECG closely and maintain normal potassium and magnesium levels.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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