Drug interactions
Asenapine + Leuprolide
Severity: Moderate
Asenapine and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide may prolong the QT interval, and asenapine adds its own QT effect. The combination may increase the risk of ventricular arrhythmia, especially in patients with other risk factors.
What this interaction means in plain words
Asenapine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation; androgen suppression is associated with QTc lengthening.
What to do
Obtain a baseline ECG and monitor QTc periodically, correcting electrolyte abnormalities. Consider an alternative antipsychotic if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Asenapine with Leuprolide?
MediHelp rates the interaction as moderate. Asenapine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with leuprolide may prolong the QT interval, and asenapine adds its own QT effect. The combination may increase the risk of ventricular arrhythmia, especially in patients with other risk factors.
How serious is the interaction between Asenapine and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically, correcting electrolyte abnormalities. Consider an alternative antipsychotic if QTc becomes markedly prolonged.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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