Drug interactions
Asenapine + Pentamidine
Severity: Major
Asenapine and Pentamidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic pentamidine is associated with QT prolongation and torsade de pointes, and asenapine has additive effects on repolarization. Hypoglycemia and electrolyte disturbances caused by pentamidine can add to the arrhythmia risk.
What this interaction means in plain words
Asenapine and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Avoid if alternatives exist; otherwise obtain a baseline ECG, correct potassium and magnesium, and monitor QTc during pentamidine treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Asenapine with Pentamidine?
MediHelp rates the interaction as major. Asenapine and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic pentamidine is associated with QT prolongation and torsade de pointes, and asenapine has additive effects on repolarization. Hypoglycemia and electrolyte disturbances caused by pentamidine can add to the arrhythmia risk.
How serious is the interaction between Asenapine and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist; otherwise obtain a baseline ECG, correct potassium and magnesium, and monitor QTc during pentamidine treatment.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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