Drug interactions
Asenapine + Propofol
Severity: Moderate
Asenapine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent sedative-hypnotic and asenapine adds sedation and alpha-blocking hypotensive effects. Together they can deepen sedation and lower blood pressure more than expected.
What this interaction means in plain words
Asenapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and vasodilatory hypotension (pharmacodynamic).
What to do
Titrate propofol cautiously with continuous monitoring of sedation depth, blood pressure and respiration. Dose reduction may be needed in patients on asenapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Propofol
Frequently asked questions
Can I take Asenapine with Propofol?
MediHelp rates the interaction as moderate. Asenapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent sedative-hypnotic and asenapine adds sedation and alpha-blocking hypotensive effects. Together they can deepen sedation and lower blood pressure more than expected.
How serious is the interaction between Asenapine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously with continuous monitoring of sedation depth, blood pressure and respiration. Dose reduction may be needed in patients on asenapine.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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