Drug interactions
Asenapine + Tasimelteon
Severity: Minor
Asenapine and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon can cause somnolence and asenapine is itself sedating, so their combination may produce more drowsiness than either alone. Impaired alertness may affect daytime activities.
What this interaction means in plain words
Asenapine and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Tasimelteon belongs to Central Nervous System.
Why it happens
Additive sedative effects from melatonin receptor agonism and the antihistaminic and antiadrenergic actions of asenapine.
What to do
Give tasimelteon at the same time each night as directed and advise caution with driving until the individual response is known. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Tasimelteon
Frequently asked questions
Can I take Asenapine with Tasimelteon?
MediHelp rates the interaction as minor. Asenapine and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tasimelteon can cause somnolence and asenapine is itself sedating, so their combination may produce more drowsiness than either alone. Impaired alertness may affect daytime activities.
How serious is the interaction between Asenapine and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give tasimelteon at the same time each night as directed and advise caution with driving until the individual response is known. No dose change is usually needed.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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