Drug interactions
Asenapine + Vilazodone
Severity: Moderate
Asenapine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is a serotonergic antidepressant and asenapine is an antipsychotic with serotonin receptor activity. Together they may rarely cause serotonin syndrome, and the combination of serotonergic activity with dopamine blockade may also raise the risk of neuroleptic malignant syndrome.
What this interaction means in plain words
Asenapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity combined with dopamine D2 antagonism, a pharmacodynamic interaction.
What to do
Monitor for mental status change, autonomic instability, clonus, hyperthermia and muscle rigidity, especially after starting the combination or increasing doses. Stop one or both drugs if features of serotonin syndrome or neuroleptic malignant syndrome appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Vilazodone?
MediHelp rates the interaction as moderate. Asenapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone is a serotonergic antidepressant and asenapine is an antipsychotic with serotonin receptor activity. Together they may rarely cause serotonin syndrome, and the combination of serotonergic activity with dopamine blockade may also raise the risk of neuroleptic malignant syndrome.
How serious is the interaction between Asenapine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, autonomic instability, clonus, hyperthermia and muscle rigidity, especially after starting the combination or increasing doses. Stop one or both drugs if features of serotonin syndrome or neuroleptic malignant syndrome appear.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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