Drug interactions
Atazanavir + Digoxin
Severity: Moderate
Atazanavir and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir prolongs PR interval and may cause AV block, which adds to digoxin's effect on AV nodal conduction. Atazanavir may also modestly increase digoxin exposure through P-gp inhibition, raising the risk of bradyarrhythmia and toxicity.
What this interaction means in plain words
Atazanavir and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Digoxin belongs to Cardiovascular.
Why it happens
Additive AV nodal conduction slowing plus possible P-glycoprotein inhibition reducing digoxin clearance.
What to do
Monitor ECG for PR prolongation and heart block and check digoxin levels. Reduce digoxin dose if levels or toxicity signs increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Digoxin?
MediHelp rates the interaction as moderate. Atazanavir and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir prolongs PR interval and may cause AV block, which adds to digoxin's effect on AV nodal conduction. Atazanavir may also modestly increase digoxin exposure through P-gp inhibition, raising the risk of bradyarrhythmia and toxicity.
How serious is the interaction between Atazanavir and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for PR prolongation and heart block and check digoxin levels. Reduce digoxin dose if levels or toxicity signs increase.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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