Drug interactions
Atazanavir + Dolasetron
Severity: Major
Atazanavir and Dolasetron: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir can prolong PR and, to a lesser degree, QT intervals, and dolasetron prolongs PR, QRS and QT intervals. Together they may increase the risk of conduction abnormalities and arrhythmia, including torsades de pointes.
What this interaction means in plain words
Atazanavir and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive effects on cardiac conduction and repolarization; atazanavir's CYP3A4 inhibition may also modestly raise hydrodolasetron exposure.
What to do
Prefer an antiemetic without cardiac conduction effects; if combined, check ECG and electrolytes at baseline and monitor for arrhythmia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Dolasetron?
MediHelp rates the interaction as major. Atazanavir and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir can prolong PR and, to a lesser degree, QT intervals, and dolasetron prolongs PR, QRS and QT intervals. Together they may increase the risk of conduction abnormalities and arrhythmia, including torsades de pointes.
How serious is the interaction between Atazanavir and Dolasetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic without cardiac conduction effects; if combined, check ECG and electrolytes at baseline and monitor for arrhythmia.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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