Drug interactions
Atazanavir + Fluconazole
Severity: Minor
Atazanavir and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may modestly raise atazanavir concentrations through CYP3A4 inhibition. Atazanavir is also a QT-relevant and PR-prolonging drug, so higher levels may matter in some patients. Clinically significant effects are uncommon.
What this interaction means in plain words
Atazanavir and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of atazanavir.
What to do
No routine dose change is needed; monitor for atazanavir adverse effects such as hyperbilirubinemia and PR prolongation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Fluconazole?
MediHelp rates the interaction as minor. Atazanavir and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may modestly raise atazanavir concentrations through CYP3A4 inhibition. Atazanavir is also a QT-relevant and PR-prolonging drug, so higher levels may matter in some patients. Clinically significant effects are uncommon.
How serious is the interaction between Atazanavir and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for atazanavir adverse effects such as hyperbilirubinemia and PR prolongation.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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