Drug interactions
Atazanavir + Glipizide
Severity: Moderate
Atazanavir and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors are associated with insulin resistance and hyperglycemia, which may reduce glipizide effectiveness. Glycemic control can deteriorate after starting therapy.
What this interaction means in plain words
Atazanavir and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Glipizide belongs to Endocrine.
Why it happens
Protease inhibitor-induced insulin resistance and impaired glucose handling oppose the sulfonylurea.
What to do
Monitor blood glucose and HbA1c after starting atazanavir and intensify antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Glipizide?
MediHelp rates the interaction as moderate. Atazanavir and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. HIV protease inhibitors are associated with insulin resistance and hyperglycemia, which may reduce glipizide effectiveness. Glycemic control can deteriorate after starting therapy.
How serious is the interaction between Atazanavir and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting atazanavir and intensify antidiabetic therapy as needed.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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