Drug interactions
Atazanavir + Linagliptin
Severity: Minor
Atazanavir and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and P-gp and may raise linagliptin levels, though linagliptin is mostly eliminated unchanged and the increase is rarely important. Protease inhibitors can also impair glucose tolerance, which may work against glycemic control.
What this interaction means in plain words
Atazanavir and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Linagliptin belongs to Endocrine.
Why it happens
CYP3A4 and P-gp inhibition by atazanavir raises linagliptin exposure, while protease inhibitor related insulin resistance may raise glucose.
What to do
No linagliptin dose change is required; monitor blood glucose and HbA1c in patients on antiretroviral therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Linagliptin?
MediHelp rates the interaction as minor. Atazanavir and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir inhibits CYP3A4 and P-gp and may raise linagliptin levels, though linagliptin is mostly eliminated unchanged and the increase is rarely important. Protease inhibitors can also impair glucose tolerance, which may work against glycemic control.
How serious is the interaction between Atazanavir and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No linagliptin dose change is required; monitor blood glucose and HbA1c in patients on antiretroviral therapy.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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