Drug interactions
Atazanavir + Modafinil
Severity: Moderate
Atazanavir and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, one pathway for modafinil metabolism, so modafinil levels may increase modestly. Modafinil is also a weak CYP3A4 inducer, which could lower atazanavir exposure. The effect is generally modest.
What this interaction means in plain words
Atazanavir and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Modafinil belongs to Central Nervous System.
Why it happens
Atazanavir inhibits CYP3A4-mediated metabolism of modafinil, and modafinil may weakly induce CYP3A4.
What to do
Monitor for modafinil adverse effects such as insomnia, anxiety, headache and raised blood pressure, and lower the dose if needed. Monitor antiretroviral virologic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Modafinil?
MediHelp rates the interaction as moderate. Atazanavir and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4, one pathway for modafinil metabolism, so modafinil levels may increase modestly. Modafinil is also a weak CYP3A4 inducer, which could lower atazanavir exposure. The effect is generally modest.
How serious is the interaction between Atazanavir and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects such as insomnia, anxiety, headache and raised blood pressure, and lower the dose if needed. Monitor antiretroviral virologic response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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