Drug interactions
Atazanavir + Trazodone
Severity: Moderate
Atazanavir and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, the main enzyme that converts trazodone to its active metabolite and clears it. Trazodone exposure can rise, increasing sedation, orthostatic hypotension and possibly QT-related effects.
What this interaction means in plain words
Atazanavir and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Trazodone belongs to Central Nervous System.
Why it happens
Atazanavir inhibits CYP3A4-mediated metabolism of trazodone.
What to do
Start trazodone at a low dose and titrate to response while monitoring for sedation, dizziness and hypotension. Reduce the trazodone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Trazodone?
MediHelp rates the interaction as moderate. Atazanavir and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4, the main enzyme that converts trazodone to its active metabolite and clears it. Trazodone exposure can rise, increasing sedation, orthostatic hypotension and possibly QT-related effects.
How serious is the interaction between Atazanavir and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start trazodone at a low dose and titrate to response while monitoring for sedation, dizziness and hypotension. Reduce the trazodone dose if adverse effects appear.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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