Drug interactions
Atenolol + Silodosin
Severity: Minor
Atenolol and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin is an alpha-1A blocker that can cause orthostatic hypotension, dizziness and syncope. Adding a beta-blocker such as atenolol may add to the blood pressure lowering effect, especially after starting treatment or increasing doses.
What this interaction means in plain words
Atenolol and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 adrenergic blockade and beta-adrenergic blockade.
What to do
Counsel the patient to rise slowly and monitor standing blood pressure when starting or adjusting either drug. Reduce the dose or separate the timing if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Silodosin?
MediHelp rates the interaction as minor. Atenolol and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Silodosin is an alpha-1A blocker that can cause orthostatic hypotension, dizziness and syncope. Adding a beta-blocker such as atenolol may add to the blood pressure lowering effect, especially after starting treatment or increasing doses.
How serious is the interaction between Atenolol and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to rise slowly and monitor standing blood pressure when starting or adjusting either drug. Reduce the dose or separate the timing if symptomatic hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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