Drug interactions
Darunavir + Silodosin
Severity: Contraindicated
Darunavir and Silodosin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir is usually given with ritonavir or cobicistat, which strongly inhibit CYP3A4 and increase silodosin exposure. This may cause pronounced hypotension and syncope.
What this interaction means in plain words
Darunavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Silodosin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 (largely via the pharmacokinetic booster) reduces silodosin clearance.
What to do
Avoid use with boosted darunavir; choose a different agent for lower urinary tract symptoms or hold silodosin during therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darunavir and Silodosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
- Ketoconazole + Silodosin Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Silodosin?
MediHelp rates the interaction as contraindicated. Darunavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir is usually given with ritonavir or cobicistat, which strongly inhibit CYP3A4 and increase silodosin exposure. This may cause pronounced hypotension and syncope.
How serious is the interaction between Darunavir and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use with boosted darunavir; choose a different agent for lower urinary tract symptoms or hold silodosin during therapy.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Fosamprenavir. The full list is on the Silodosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
