Drug interactions
Fosamprenavir + Silodosin
Severity: Contraindicated
Fosamprenavir and Silodosin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, and is often boosted with ritonavir. Silodosin exposure may increase, raising the risk of hypotension and syncope.
What this interaction means in plain words
Fosamprenavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Amprenavir (especially ritonavir-boosted) inhibits CYP3A4 and reduces silodosin clearance.
What to do
Avoid the combination; use an alternative to silodosin or hold it during antiretroviral therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
- Ketoconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Silodosin?
MediHelp rates the interaction as contraindicated. Fosamprenavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, and is often boosted with ritonavir. Silodosin exposure may increase, raising the risk of hypotension and syncope.
How serious is the interaction between Fosamprenavir and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative to silodosin or hold it during antiretroviral therapy.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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