Drug interactions
Indinavir + Silodosin
Severity: Contraindicated
Indinavir and Silodosin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A4 inhibitor. Strong inhibitors markedly increase silodosin exposure, which raises the risk of orthostatic hypotension and syncope.
What this interaction means in plain words
Indinavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Indinavir strongly inhibits CYP3A4, markedly reducing silodosin metabolism.
What to do
Do not co-administer; silodosin labeling contraindicates strong CYP3A4 inhibitors. Use an alternative BPH therapy or antiretroviral.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indinavir and Silodosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
- Ketoconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Indinavir with Silodosin?
MediHelp rates the interaction as contraindicated. Indinavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Indinavir is a strong CYP3A4 inhibitor. Strong inhibitors markedly increase silodosin exposure, which raises the risk of orthostatic hypotension and syncope.
How serious is the interaction between Indinavir and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; silodosin labeling contraindicates strong CYP3A4 inhibitors. Use an alternative BPH therapy or antiretroviral.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
