Drug reference
silodosin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Genitourinary (Alpha-1 Blockers)
Mechanism of action
Selective antagonist of postsynaptic alpha-1-adrenoceptors; blocking the alpha1A-adrenoreceptors in the smooth muscle of the prostate leads to relaxation of the smooth muscle in the bladder neck and prostate causing an improvement of urine flow and decreased symptom of BPH.
Common side effects
- Retrograde ejaculation
- Nasopharyngitis
- Dizziness
- Headache
- Diarrhea
Contraindications
- Hypersensitivity Severe renal impairment (CrCl <30 mL/min) Severe hepatic impairment (Child-Pugh Score >10) Concomitant strong CYP3A4 inhibitors or P-glycoprotein inhibitors
Known interactions (7)
- itraconazole + silodosin Contraindicated
- aprepitant + silodosin Moderate
- dasatinib + silodosin Moderate
- dronedarone + silodosin Moderate
- efavirenz + silodosin Moderate
- fluconazole + silodosin Moderate
- griseofulvin + silodosin Moderate
Related conditions
Frequently asked questions
What drug class is silodosin?
silodosin belongs to: Genitourinary.
How does silodosin work?
Selective antagonist of postsynaptic alpha-1-adrenoceptors; blocking the alpha1A-adrenoreceptors in the smooth muscle of the prostate leads to relaxation of the smooth muscle in the bladder neck and prostate causing an improvement of urine flow and decreased symptom of BPH.
What are the common side effects of silodosin?
Retrograde ejaculation, Nasopharyngitis, Dizziness, Headache, Diarrhea
Which drugs interact with silodosin?
itraconazole, aprepitant, dasatinib, dronedarone, efavirenz, fluconazole, griseofulvin
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