Drug interactions
Conivaptan + Silodosin
Severity: Contraindicated
Conivaptan and Silodosin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and may raise silodosin levels. Excessive alpha-blockade can cause orthostatic hypotension, which is more concerning in patients receiving conivaptan for hyponatremia.
What this interaction means in plain words
Conivaptan and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Conivaptan inhibits CYP3A4, decreasing silodosin metabolism.
What to do
Avoid concurrent use; hold silodosin while conivaptan is given, which is usually short-term inpatient therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
- Ketoconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Conivaptan with Silodosin?
MediHelp rates the interaction as contraindicated. Conivaptan and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a strong CYP3A4 inhibitor and may raise silodosin levels. Excessive alpha-blockade can cause orthostatic hypotension, which is more concerning in patients receiving conivaptan for hyponatremia.
How serious is the interaction between Conivaptan and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; hold silodosin while conivaptan is given, which is usually short-term inpatient therapy.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Darunavir, Fosamprenavir. The full list is on the Silodosin page.
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