Drug interactions
Atazanavir + Silodosin
Severity: Contraindicated
Atazanavir and Silodosin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and can increase silodosin exposure. This raises the risk of marked orthostatic hypotension and syncope.
What this interaction means in plain words
Atazanavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Silodosin belongs to Genitourinary.
Why it happens
Atazanavir inhibits CYP3A4, reducing the metabolic clearance of silodosin.
What to do
Avoid the combination in line with silodosin labeling on strong CYP3A4 inhibitors; consider tamsulosin alternatives only with caution or non-alpha-blocker options.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Silodosin
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
- Ketoconazole + Silodosin Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Silodosin?
MediHelp rates the interaction as contraindicated. Atazanavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir is a strong CYP3A4 inhibitor and can increase silodosin exposure. This raises the risk of marked orthostatic hypotension and syncope.
How serious is the interaction between Atazanavir and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in line with silodosin labeling on strong CYP3A4 inhibitors; consider tamsulosin alternatives only with caution or non-alpha-blocker options.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Conivaptan, Darunavir, Fosamprenavir. The full list is on the Silodosin page.
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