Drug interactions
Atenolol-chlorthalidone + Porfimer
Severity: Moderate
Atenolol-chlorthalidone and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is a sulfonamide-derived thiazide-like diuretic that can cause photosensitivity. Porfimer is a photosensitizing agent used in photodynamic therapy, so combined use may intensify or prolong skin photosensitivity reactions.
What this interaction means in plain words
Atenolol-chlorthalidone and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects (pharmacodynamic synergism).
What to do
Counsel strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling, and consider temporarily replacing chlorthalidone if clinically feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Porfimer
Frequently asked questions
Can I take Atenolol-chlorthalidone with Porfimer?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone is a sulfonamide-derived thiazide-like diuretic that can cause photosensitivity. Porfimer is a photosensitizing agent used in photodynamic therapy, so combined use may intensify or prolong skin photosensitivity reactions.
How serious is the interaction between Atenolol-chlorthalidone and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling, and consider temporarily replacing chlorthalidone if clinically feasible.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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