Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Porfimer
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a photosensitizing drug, and porfimer causes marked photosensitivity after photodynamic therapy. Together they may increase the risk or severity of phototoxic skin reactions.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects.
What to do
Counsel strict avoidance of sunlight and bright indoor light for the period specified in the porfimer labeling. Consider whether the thiazide can be held or changed during that time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Porfimer
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Porfimer?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a photosensitizing drug, and porfimer causes marked photosensitivity after photodynamic therapy. Together they may increase the risk or severity of phototoxic skin reactions.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict avoidance of sunlight and bright indoor light for the period specified in the porfimer labeling. Consider whether the thiazide can be held or changed during that time.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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