Drug interactions
Argatroban + Porfimer
Severity: Moderate
Argatroban and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Porfimer is a photosensitizer used in photodynamic therapy. Its labeling notes that drugs affecting coagulation might decrease the efficacy of the therapy, because vascular occlusion contributes to tumor destruction; argatroban is not clearly established to do this.
What this interaction means in plain words
Argatroban and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Anticoagulation may impair thrombus formation that contributes to the effect of photodynamic therapy.
What to do
Consider timing of anticoagulation relative to photodynamic therapy with the treating oncologist, and monitor for bleeding at the treatment site.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Porfimer
- Amlodipine-hydrochlorothiazide-valsartan + Porfimer Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Porfimer Moderate
- Atenolol-chlorthalidone + Porfimer Moderate
- Azilsartan-chlorthalidone + Porfimer Moderate
- Candesartan-hydrochlorothiazide + Porfimer Moderate
- Captopril-hydrochlorothiazide + Porfimer Moderate
Frequently asked questions
Can I take Argatroban with Porfimer?
MediHelp rates the interaction as moderate. Argatroban and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Porfimer is a photosensitizer used in photodynamic therapy. Its labeling notes that drugs affecting coagulation might decrease the efficacy of the therapy, because vascular occlusion contributes to tumor destruction; argatroban is not clearly established to do this.
How serious is the interaction between Argatroban and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider timing of anticoagulation relative to photodynamic therapy with the treating oncologist, and monitor for bleeding at the treatment site.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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