Drug interactions
Candesartan-hydrochlorothiazide + Porfimer
Severity: Moderate
Candesartan-hydrochlorothiazide and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is photosensitizing and may add to the photosensitivity reactions seen after porfimer photodynamic therapy. This increases the risk of skin burns on sun exposure.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive phototoxic potential from two photosensitizing agents.
What to do
Counsel strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling, and consider whether hydrochlorothiazide can be temporarily replaced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Porfimer
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Porfimer?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is photosensitizing and may add to the photosensitivity reactions seen after porfimer photodynamic therapy. This increases the risk of skin burns on sun exposure.
How serious is the interaction between Candesartan-hydrochlorothiazide and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling, and consider whether hydrochlorothiazide can be temporarily replaced.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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