Drug interactions
Azilsartan-chlorthalidone + Porfimer
Severity: Moderate
Azilsartan-chlorthalidone and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is a photosensitizing drug, and porfimer causes marked photosensitivity as part of photodynamic therapy. Using both may increase the risk or severity of skin phototoxic reactions.
What this interaction means in plain words
Azilsartan-chlorthalidone and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects of a thiazide-like diuretic and a photosensitizer.
What to do
Counsel the patient to avoid sunlight and bright indoor light and to use protective clothing for the period specified in porfimer labeling. Consider whether chlorthalidone can be temporarily replaced if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Porfimer
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Porfimer?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone is a photosensitizing drug, and porfimer causes marked photosensitivity as part of photodynamic therapy. Using both may increase the risk or severity of skin phototoxic reactions.
How serious is the interaction between Azilsartan-chlorthalidone and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid sunlight and bright indoor light and to use protective clothing for the period specified in porfimer labeling. Consider whether chlorthalidone can be temporarily replaced if feasible.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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