Drug interactions
Captopril-hydrochlorothiazide + Porfimer
Severity: Moderate
Captopril-hydrochlorothiazide and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a photosensitizing drug and may add to the photosensitivity caused by porfimer during photodynamic therapy. This may increase the risk of sunburn-like skin reactions.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive phototoxic effects of two photosensitizing agents.
What to do
Reinforce strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling. Consider temporarily switching the thiazide if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Porfimer
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Porfimer?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a photosensitizing drug and may add to the photosensitivity caused by porfimer during photodynamic therapy. This may increase the risk of sunburn-like skin reactions.
How serious is the interaction between Captopril-hydrochlorothiazide and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reinforce strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling. Consider temporarily switching the thiazide if feasible.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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