Drug interactions
Atogepant + Fluvoxamine
Severity: Minor
Atogepant and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is a CYP3A4 substrate, and fluvoxamine is a weak CYP3A4 inhibitor. Exposure to atogepant may rise modestly, which could increase adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Atogepant and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by fluvoxamine decreases atogepant metabolism.
What to do
No dose change is usually needed; monitor tolerability. Dose limits in labeling apply to strong and moderate CYP3A4 inhibitors rather than weak ones.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Fluvoxamine?
MediHelp rates the interaction as minor. Atogepant and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is a CYP3A4 substrate, and fluvoxamine is a weak CYP3A4 inhibitor. Exposure to atogepant may rise modestly, which could increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor tolerability. Dose limits in labeling apply to strong and moderate CYP3A4 inhibitors rather than weak ones.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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