Drug interactions
Atogepant + Lurasidone
Severity: Minor
Atogepant and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is a CYP3A4 substrate. Lurasidone is a weak CYP3A4 inhibitor at most, so any increase in atogepant exposure is expected to be small and unlikely to be clinically important.
What this interaction means in plain words
Atogepant and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4-mediated metabolism of atogepant.
What to do
No dose adjustment is generally needed. Be aware of increased atogepant adverse effects such as nausea or constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Lurasidone?
MediHelp rates the interaction as minor. Atogepant and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is a CYP3A4 substrate. Lurasidone is a weak CYP3A4 inhibitor at most, so any increase in atogepant exposure is expected to be small and unlikely to be clinically important.
How serious is the interaction between Atogepant and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Be aware of increased atogepant adverse effects such as nausea or constipation.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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