Drug interactions
Atogepant + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Atogepant and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxilaprevir inhibits OATP1B1 and OATP1B3, which transport atogepant into the liver, so atogepant exposure may increase. This raises the risk of dose-related adverse effects such as nausea and constipation.
What this interaction means in plain words
Atogepant and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
OATP1B1/1B3 inhibition by voxilaprevir decreases hepatic uptake of atogepant.
What to do
Limit atogepant to 10 mg or 30 mg once daily as per labeling for OATP inhibitors, and monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Atogepant and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxilaprevir inhibits OATP1B1 and OATP1B3, which transport atogepant into the liver, so atogepant exposure may increase. This raises the risk of dose-related adverse effects such as nausea and constipation.
How serious is the interaction between Atogepant and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to 10 mg or 30 mg once daily as per labeling for OATP inhibitors, and monitor tolerability.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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