Drug interactions
Atogepant + Tacrolimus
Severity: Moderate
Atogepant and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may inhibit hepatic uptake transporters such as OATP1B1, which could raise atogepant exposure. Higher atogepant levels may increase adverse effects such as constipation, nausea and fatigue.
What this interaction means in plain words
Atogepant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Possible inhibition of OATP-mediated hepatic uptake of atogepant by tacrolimus.
What to do
Limit atogepant to the lower doses recommended with OATP inhibitors (10 mg or 30 mg daily). Monitor for tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Tacrolimus?
MediHelp rates the interaction as moderate. Atogepant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may inhibit hepatic uptake transporters such as OATP1B1, which could raise atogepant exposure. Higher atogepant levels may increase adverse effects such as constipation, nausea and fatigue.
How serious is the interaction between Atogepant and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to the lower doses recommended with OATP inhibitors (10 mg or 30 mg daily). Monitor for tolerability.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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