Drug interactions
Atomoxetine + Givosiran
Severity: Moderate
Atomoxetine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can raise exposure to drugs cleared by CYP2D6, which is the main metabolic pathway of atomoxetine. Higher atomoxetine levels may increase adverse effects such as tachycardia, blood pressure elevation, insomnia and agitation.
What this interaction means in plain words
Atomoxetine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran reduces CYP2D6 activity, decreasing atomoxetine clearance.
What to do
Monitor heart rate, blood pressure and adverse effects, and reduce the atomoxetine dose if intolerance occurs. Follow labeling guidance on dose reduction for sensitive CYP2D6 substrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Atomoxetine with Givosiran?
MediHelp rates the interaction as moderate. Atomoxetine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can raise exposure to drugs cleared by CYP2D6, which is the main metabolic pathway of atomoxetine. Higher atomoxetine levels may increase adverse effects such as tachycardia, blood pressure elevation, insomnia and agitation.
How serious is the interaction between Atomoxetine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and adverse effects, and reduce the atomoxetine dose if intolerance occurs. Follow labeling guidance on dose reduction for sensitive CYP2D6 substrates.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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