Drug interactions
Duloxetine + Givosiran
Severity: Major
Duloxetine and Givosiran: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran reduces activity of CYP1A2 and CYP2D6, the two main pathways for duloxetine, so duloxetine concentrations may rise substantially. This could increase nausea, dizziness, blood pressure effects and serotonin toxicity.
What this interaction means in plain words
Duloxetine and Givosiran can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran-related reduction of CYP1A2 and CYP2D6 activity decreases duloxetine metabolism.
What to do
Avoid the combination if possible. If necessary, use a lower duloxetine dose and monitor for adverse effects and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Givosiran
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
- Amitriptyline + Givosiran Moderate
Frequently asked questions
Can I take Duloxetine with Givosiran?
MediHelp rates the interaction as major. Duloxetine and Givosiran can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givosiran reduces activity of CYP1A2 and CYP2D6, the two main pathways for duloxetine, so duloxetine concentrations may rise substantially. This could increase nausea, dizziness, blood pressure effects and serotonin toxicity.
How serious is the interaction between Duloxetine and Givosiran?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, use a lower duloxetine dose and monitor for adverse effects and blood pressure.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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