Drug interactions
Givosiran + Tizanidine
Severity: Major
Givosiran and Tizanidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity, and tizanidine is a sensitive CYP1A2 substrate with extensive first-pass metabolism. Higher tizanidine exposure may cause marked hypotension, bradycardia and sedation.
What this interaction means in plain words
Givosiran and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givosiran belongs to Miscellaneous; Tizanidine belongs to Musculoskeletal.
Why it happens
Givosiran inhibits CYP1A2-mediated metabolism, raising tizanidine plasma concentrations.
What to do
Avoid the combination where possible. If unavoidable, lower the tizanidine dose and monitor blood pressure, heart rate and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Amitriptyline + Givosiran Moderate
Frequently asked questions
Can I take Givosiran with Tizanidine?
MediHelp rates the interaction as major. Givosiran and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givosiran can reduce CYP1A2 activity, and tizanidine is a sensitive CYP1A2 substrate with extensive first-pass metabolism. Higher tizanidine exposure may cause marked hypotension, bradycardia and sedation.
How serious is the interaction between Givosiran and Tizanidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, lower the tizanidine dose and monitor blood pressure, heart rate and sedation.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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