Drug interactions
Givosiran + Thioridazine
Severity: Major
Givosiran and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, which may increase thioridazine concentrations. Because thioridazine is metabolized by CYP2D6 and dose-dependently prolongs QT, higher levels raise the risk of arrhythmia.
What this interaction means in plain words
Givosiran and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givosiran belongs to Miscellaneous; Thioridazine belongs to Central Nervous System.
Why it happens
Givosiran-associated inhibition of CYP2D6 reduces thioridazine clearance.
What to do
Avoid the combination where possible. If used, reduce the thioridazine dose and monitor ECG/QTc and signs of thioridazine toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Tizanidine Major
- Amitriptyline + Givosiran Moderate
Frequently asked questions
Can I take Givosiran with Thioridazine?
MediHelp rates the interaction as major. Givosiran and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givosiran can reduce CYP2D6 activity, which may increase thioridazine concentrations. Because thioridazine is metabolized by CYP2D6 and dose-dependently prolongs QT, higher levels raise the risk of arrhythmia.
How serious is the interaction between Givosiran and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, reduce the thioridazine dose and monitor ECG/QTc and signs of thioridazine toxicity.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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