Drug interactions
Givosiran + Propafenone
Severity: Major
Givosiran and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, and propafenone depends on CYP2D6 for its metabolism. Propafenone exposure may rise, increasing the risk of proarrhythmia, conduction abnormalities and neurological adverse effects.
What this interaction means in plain words
Givosiran and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givosiran belongs to Miscellaneous; Propafenone belongs to Cardiovascular.
Why it happens
Givosiran reduces CYP2D6-mediated metabolism of propafenone.
What to do
Avoid coadministration if possible. If it cannot be avoided, lower the propafenone dose and monitor ECG and clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
- Amitriptyline + Givosiran Moderate
Frequently asked questions
Can I take Givosiran with Propafenone?
MediHelp rates the interaction as major. Givosiran and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givosiran can reduce CYP2D6 activity, and propafenone depends on CYP2D6 for its metabolism. Propafenone exposure may rise, increasing the risk of proarrhythmia, conduction abnormalities and neurological adverse effects.
How serious is the interaction between Givosiran and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration if possible. If it cannot be avoided, lower the propafenone dose and monitor ECG and clinical response.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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