Drug interactions
Givosiran + Theophylline
Severity: Major
Givosiran and Theophylline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity, and theophylline depends mainly on CYP1A2 for clearance. Theophylline levels may therefore climb, bringing risk of nausea, tachycardia, arrhythmia and seizures.
What this interaction means in plain words
Givosiran and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givosiran belongs to Miscellaneous; Theophylline belongs to Respiratory.
Why it happens
Givosiran decreases CYP1A2 activity, reducing hepatic clearance of theophylline.
What to do
Avoid the combination where possible; if it is needed, lower the theophylline dose and monitor serum concentrations and clinical signs of toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Givosiran and Theophylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
- Amitriptyline + Givosiran Moderate
Frequently asked questions
Can I take Givosiran with Theophylline?
MediHelp rates the interaction as major. Givosiran and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givosiran can reduce CYP1A2 activity, and theophylline depends mainly on CYP1A2 for clearance. Theophylline levels may therefore climb, bringing risk of nausea, tachycardia, arrhythmia and seizures.
How serious is the interaction between Givosiran and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is needed, lower the theophylline dose and monitor serum concentrations and clinical signs of toxicity.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
