Drug interactions
Givosiran + Pimozide
Severity: Major
Givosiran and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can increase exposure to CYP1A2 and CYP2D6 substrates, and pimozide is metabolized partly by both. Increased pimozide levels raise the risk of QT prolongation and arrhythmia.
What this interaction means in plain words
Givosiran and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givosiran belongs to Miscellaneous; Pimozide belongs to Central Nervous System.
Why it happens
Givosiran reduces CYP1A2 and CYP2D6 activity, decreasing pimozide clearance.
What to do
Avoid the combination where possible. If needed, reduce the pimozide dose and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
- Amitriptyline + Givosiran Moderate
Frequently asked questions
Can I take Givosiran with Pimozide?
MediHelp rates the interaction as major. Givosiran and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givosiran can increase exposure to CYP1A2 and CYP2D6 substrates, and pimozide is metabolized partly by both. Increased pimozide levels raise the risk of QT prolongation and arrhythmia.
How serious is the interaction between Givosiran and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If needed, reduce the pimozide dose and monitor the ECG.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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