Drug interactions
Atorvastatin + Elagolix
Severity: Moderate
Atorvastatin and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and also inhibits P-gp, giving opposing effects on atorvastatin. Net exposure may change unpredictably, with possible loss of efficacy or increased exposure.
What this interaction means in plain words
Atorvastatin and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Elagolix belongs to Musculoskeletal.
Why it happens
Elagolix induces CYP3A4 while inhibiting P-glycoprotein, altering atorvastatin metabolism and absorption.
What to do
Monitor lipid response and muscle symptoms during coadministration, and adjust the atorvastatin dose according to response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Atorvastatin with Elagolix?
MediHelp rates the interaction as moderate. Atorvastatin and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and also inhibits P-gp, giving opposing effects on atorvastatin. Net exposure may change unpredictably, with possible loss of efficacy or increased exposure.
How serious is the interaction between Atorvastatin and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and muscle symptoms during coadministration, and adjust the atorvastatin dose according to response and tolerability.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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