Drug interactions
Atorvastatin + Nintedanib
Severity: Minor
Atorvastatin and Nintedanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nintedanib is a P-glycoprotein substrate, and atorvastatin is a weak P-gp inhibitor, so nintedanib exposure may rise slightly. The effect is unlikely to be clinically significant.
What this interaction means in plain words
Atorvastatin and Nintedanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
Weak P-glycoprotein inhibition by atorvastatin may reduce nintedanib efflux.
What to do
No dose change is usually needed. Monitor for gastrointestinal effects and liver enzyme elevation, which are typical of nintedanib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Atorvastatin with Nintedanib?
MediHelp rates the interaction as minor. Atorvastatin and Nintedanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nintedanib is a P-glycoprotein substrate, and atorvastatin is a weak P-gp inhibitor, so nintedanib exposure may rise slightly. The effect is unlikely to be clinically significant.
How serious is the interaction between Atorvastatin and Nintedanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for gastrointestinal effects and liver enzyme elevation, which are typical of nintedanib.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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