Drug interactions
Atropine + Digoxin
Severity: Minor
Atropine and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergic drugs like atropine slow gastrointestinal motility, which can increase absorption of slowly dissolving digoxin tablets and raise levels. Atropine also opposes vagal effects of digoxin on heart rate, so the net clinical effect is variable.
What this interaction means in plain words
Atropine and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atropine belongs to Miscellaneous; Digoxin belongs to Cardiovascular.
Why it happens
Reduced gut motility prolongs digoxin dissolution and absorption time; opposing vagal effects on the heart.
What to do
Monitor heart rate and rhythm, and check digoxin levels if prolonged anticholinergic therapy is used. Watch for signs of digoxin toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Digoxin?
MediHelp rates the interaction as minor. Atropine and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anticholinergic drugs like atropine slow gastrointestinal motility, which can increase absorption of slowly dissolving digoxin tablets and raise levels. Atropine also opposes vagal effects of digoxin on heart rate, so the net clinical effect is variable.
How serious is the interaction between Atropine and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm, and check digoxin levels if prolonged anticholinergic therapy is used. Watch for signs of digoxin toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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