Drug interactions
Atropine + Tiotropium-olodaterol
Severity: Moderate
Atropine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine given systemically adds antimuscarinic effects to tiotropium, which may increase dry mouth, tachycardia, urinary retention and constipation. Ocular atropine has minimal systemic exposure, so the interaction mostly matters with systemic dosing.
What this interaction means in plain words
Atropine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid unnecessary co-administration of systemic anticholinergics with tiotropium; monitor for tachycardia, urinary retention and eye pain, particularly in glaucoma or prostatic enlargement.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Atropine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine given systemically adds antimuscarinic effects to tiotropium, which may increase dry mouth, tachycardia, urinary retention and constipation. Ocular atropine has minimal systemic exposure, so the interaction mostly matters with systemic dosing.
How serious is the interaction between Atropine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary co-administration of systemic anticholinergics with tiotropium; monitor for tachycardia, urinary retention and eye pain, particularly in glaucoma or prostatic enlargement.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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