Drug interactions
Atropine + Trazodone
Severity: Minor
Atropine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has weak anticholinergic activity, which may modestly add to the effects of atropine such as dry mouth, constipation, urinary retention or tachycardia. The effect is usually small at ordinary doses.
What this interaction means in plain words
Atropine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atropine belongs to Miscellaneous; Trazodone belongs to Central Nervous System.
Why it happens
Additive weak antimuscarinic effects.
What to do
Monitor for anticholinergic effects such as urinary retention, constipation and confusion, especially in older adults.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Trazodone?
MediHelp rates the interaction as minor. Atropine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone has weak anticholinergic activity, which may modestly add to the effects of atropine such as dry mouth, constipation, urinary retention or tachycardia. The effect is usually small at ordinary doses.
How serious is the interaction between Atropine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, constipation and confusion, especially in older adults.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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