Drug interactions
Avanafil + Belzutifan
Severity: Moderate
Avanafil and Belzutifan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may reduce avanafil concentrations, which can lead to loss of erectile response.
What this interaction means in plain words
Avanafil and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Belzutifan belongs to Miscellaneous.
Why it happens
Belzutifan induces CYP3A4, increasing avanafil metabolism.
What to do
Monitor erectile response and consider a higher avanafil dose within labeled limits, or choose an alternative if efficacy is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Avanafil with Belzutifan?
MediHelp rates the interaction as moderate. Avanafil and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may reduce avanafil concentrations, which can lead to loss of erectile response.
How serious is the interaction between Avanafil and Belzutifan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor erectile response and consider a higher avanafil dose within labeled limits, or choose an alternative if efficacy is inadequate.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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