Drug interactions
Avanafil + Chlorthalidone
Severity: Moderate
Avanafil and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil may add to the blood pressure lowering effect of thiazide-like diuretics. Symptomatic hypotension is more likely if the patient is volume depleted.
What this interaction means in plain words
Avanafil and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Chlorthalidone belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from PDE5-mediated vasodilation and diuretic-induced volume depletion.
What to do
Ensure adequate hydration and stable blood pressure before starting avanafil. Monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Avanafil with Chlorthalidone?
MediHelp rates the interaction as moderate. Avanafil and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil may add to the blood pressure lowering effect of thiazide-like diuretics. Symptomatic hypotension is more likely if the patient is volume depleted.
How serious is the interaction between Avanafil and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and stable blood pressure before starting avanafil. Monitor blood pressure and orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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