Drug interactions
Avanafil + Cyclosporin
Severity: Moderate
Avanafil and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase avanafil exposure, raising the risk of hypotension, headache, flushing and priapism. The labeling limits avanafil dosing with moderate CYP3A4 inhibitors.
What this interaction means in plain words
Avanafil and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4, reducing avanafil clearance.
What to do
Limit avanafil to 50 mg no more than once every 24 hours and monitor for hypotension and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Cyclosporin?
MediHelp rates the interaction as moderate. Avanafil and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase avanafil exposure, raising the risk of hypotension, headache, flushing and priapism. The labeling limits avanafil dosing with moderate CYP3A4 inhibitors.
How serious is the interaction between Avanafil and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit avanafil to 50 mg no more than once every 24 hours and monitor for hypotension and adverse effects.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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