Drug interactions
Avanafil + Eprosartan-hydrochlorothiazide
Severity: Moderate
Avanafil and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor with vasodilating properties and can add to the blood pressure lowering of eprosartan and hydrochlorothiazide. Symptomatic hypotension is possible, particularly with volume depletion.
What this interaction means in plain words
Avanafil and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure reduction via PDE5 inhibition and antihypertensive therapy.
What to do
Use the lowest avanafil dose first and monitor blood pressure and orthostatic symptoms. Counsel patients on rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Avanafil and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor with vasodilating properties and can add to the blood pressure lowering of eprosartan and hydrochlorothiazide. Symptomatic hypotension is possible, particularly with volume depletion.
How serious is the interaction between Avanafil and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest avanafil dose first and monitor blood pressure and orthostatic symptoms. Counsel patients on rising slowly.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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