Drug interactions
Avanafil + Erythromycin
Severity: Major
Avanafil and Erythromycin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin reduces avanafil clearance and increases its exposure, which may heighten hypotension, headache, flushing and other adverse effects.
What this interaction means in plain words
Avanafil and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avanafil belongs to Genitourinary; Erythromycin belongs to Anti Bacterial.
Why it happens
Moderate CYP3A4 inhibition by erythromycin decreases avanafil metabolism.
What to do
Limit avanafil to a maximum of 50 mg no more than once every 24 hours during erythromycin use. Counsel the patient about hypotension symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Erythromycin?
MediHelp rates the interaction as major. Avanafil and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin reduces avanafil clearance and increases its exposure, which may heighten hypotension, headache, flushing and other adverse effects.
How serious is the interaction between Avanafil and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit avanafil to a maximum of 50 mg no more than once every 24 hours during erythromycin use. Counsel the patient about hypotension symptoms.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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