Drug interactions
Avanafil + Hydrochlorothiazide-valsartan
Severity: Moderate
Avanafil and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor that causes vasodilation and lowers blood pressure, and this adds to the effect of valsartan and hydrochlorothiazide. Symptomatic hypotension or dizziness may occur, particularly at treatment start or with volume depletion.
What this interaction means in plain words
Avanafil and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure lowering from PDE5 inhibition and antihypertensive therapy.
What to do
Start avanafil at the lowest dose and counsel about orthostatic symptoms. Ensure blood pressure is stable and patients are not volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Avanafil and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor that causes vasodilation and lowers blood pressure, and this adds to the effect of valsartan and hydrochlorothiazide. Symptomatic hypotension or dizziness may occur, particularly at treatment start or with volume depletion.
How serious is the interaction between Avanafil and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at the lowest dose and counsel about orthostatic symptoms. Ensure blood pressure is stable and patients are not volume depleted.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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