Drug interactions
Avanafil + Istradefylline
Severity: Moderate
Avanafil and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg/day raises exposure to CYP3A4 substrates, so avanafil levels may increase. This could heighten hypotension and other adverse effects.
What this interaction means in plain words
Avanafil and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits CYP3A4 at higher doses, decreasing avanafil clearance.
What to do
Consider limiting avanafil to 50 mg once daily if istradefylline 40 mg/day is used, and monitor for hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Avanafil with Istradefylline?
MediHelp rates the interaction as moderate. Avanafil and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at 40 mg/day raises exposure to CYP3A4 substrates, so avanafil levels may increase. This could heighten hypotension and other adverse effects.
How serious is the interaction between Avanafil and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider limiting avanafil to 50 mg once daily if istradefylline 40 mg/day is used, and monitor for hypotension.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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